Vol 1-1 Mini Review

New approaches to determining financial capacity and risk for exploitation

Peter A. Lichtenberg

Institute of Gerontology & Merrill Palmer Skillman Institute, Wayne State University, USA

DOI: 10.29245/2578-2959/2018/1.1100 View / Download Pdf
Vol 1-1 Research

Motor impairment in children with autistic spectrum disorder and in children with attention deficit hyperactivity disorder

Maria Pia Bucci1*, Nathalie Goulème1,2, Coline Stordeur3, Eric Acquaviva3, Mathilde Septier3, Aline Lefebvre3, Hugo Peyre3,4,5, Richard Delorme3,4,5

1UMR 1141 Inserm - Paris Diderot University. Robert Debré Hospital, Paris, France
2Lyon Neuroscience Research Center (Inserm U1028 CNRS UMR5292), Lyon, France & Department of Audiology and Otoneurological Evaluation, Civil Hospitals of Lyon, Lyon, France
3Child and Adolescent Psychiatry Department, Robert Debré Hospital, Paris, France
4Paris Diderot University, Paris 7, France
5High Functioning Autism Expert Centre, Fondamental Foundation, Paris, France

We summarize postural instabilities in children with autistic spectrum disorder (ASD) and in children with attention deficit hyperactivity disorder (ADHD), and we reported behavioral results suggesting poor cerebellar integration. We conclude that postural measures could be a promising method with which to indirectly observe cerebellar performance in children developmental disabilities such as ASD and/or ADHD.

DOI: 10.29245/2578-2959/2018/1.1101 View / Download Pdf
Vol 1-1 Mini Review

Elucidating the Mechanism(s) Underlying Antipsychotic- and Antidepressant-Mediated Fractures

Karen L. Houseknecht1,2*, C.C. Bouchard1, C.A Black2

1College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, ME 04005, USA
2College of Pharmacy, University of New England, 716 Stevens Avenue, Portland, Maine 04013, USA

Mood spectrum disorders and medications used to treat these disorders, such as atypical antipsychotic drugs (AA), are associated with metabolic and endocrine side effects including obesity, dyslipidemia, hyperglycemia and increased risk of fractures. Antidepressant medications, including selective serotonin reuptake inhibitors (SSRI), have also been reported to increase fracture risk in some patients. The pharmacology underlying the increased risk of fractures is currently unknown. Possible mechanisms include alternations in dopaminergic and/or serotonergic signaling pathways. As these medications distribute to the bone marrow as well as to the brain, it is possible that drug-induced fractures are due to both centrally mediated effects as well as direct effects on bone turnover. Given the growing patient population that is prescribed these medications for both on- and off-label indications, understanding the level of risk and the mechanisms underlying drug-induced fractures is important for informing both prescribing and patient monitoring practices.

DOI: 10.29245/2578-2959/2018/1.1106 View / Download Pdf
Vol 1-1 Mini Review

Pathways early intervention program for toddlers with autism

Pamela Rosenthal Rollins*

University of Texas at Dallas, Callier Center for Communication Disorders, 1966 Inwood Road, Dallas, USA

Early identification and intervention that focus on the core social deficits of children with autism spectrum disorder (ASD) are imperative for these children to be able to reach their optimal potential. This report examines the Pathways Early Autism Intervention (Pathways), a translational parent-mediated, naturalistic developmental behavioral intervention (NDBI) for toddlers with ASD. Pathways fits the service delivery model and principles of Texas’ state-funded Early Childhood Intervention (ECI) programs. Pathways was found to be more effective than traditional ECI programs in improving early foundational social communication skills and in reducing parental stress in culturally and economically diverse toddlers with ASD. Pathways shows promise as an effective ASD specific intervention with the potential of being implemented within publicly funded ECI programs.

DOI: 10.29245/2578-2959/2018/1.1104 View / Download Pdf