Association Between Depression and Recurrence of Peptic Ulcer Disease in Older Chinese Patients after Helicobacter Pylori Eradication: A Three-Year Study
Wenni Chen, Yu Yu, Ruirui Xu, Hui Han, Gengzhen Chen*
Shantou University Medical College, Shantou, China
Background: Both Helicobacter pylori-infected peptic ulcer disease (PUD) and depression are common in older adults. Although H. helicobacter eradication has significantly reduced the risk of PUD recurrence, it remains unknown whether such therapy achieves comparable effect among older patients with and without depression.
Aim: To compare PUD recurrence rates in depressed and non-depressed older patients after successful H. pylori eradication, and to evaluate the prospective effect of self-reported and diagnosed depression on PUD recurrence.
Methods: 978 older patients with previous H. pylori-infected PUD were included after H. pylori eradication, and followed for up to 36 months. Using endoscopic examination, PUD recurrence rates among depressed and non-depressed older patients were compared. Multivariate logistic regression was performed to ascertain the prospective relationship between depression and PUD recurrence.
Results: PUD recurrence rate was higher in patients with self-reported depression (10.9%) than those without (6.2%). Apart from self-reported depression (OR 2.418 (1.232, 4.989), other significant predictors of PUD recurrence included H. pylori reinfection (OR 2.815 (1.198, 4.687), cigarette smoking (OR 2.318 (1.238, 4.862), excessive alcohol drinking (OR 2.287 (1.118, 4.677), high green tea consumption (OR 2.107 (1.025, 4.325), regular ingestion of acetaminophen (OR 2.273 (1.238, 4.218) and NSAIDs (OR 3.341 (2.174, 5.187), as well as regular (OR 3.372 (2.087, 5.298), occasional (OR 3.096 (2.032, 5.162), and infrequent aspirin consumption (OR 2.645 (1.218, 4.562). Similar results were yielded on the association between diagnosed depression and PUD recurrence.
Conclusion: PUD recurrence following H. pylori eradication is higher in depressed than in non-depressed older patients. PUD recurrence is also attributed by other clinical and behavioral factors. Results of this study sheds lights on the pathways underlying the association between multidimensional factors and PUD recurrence, which provides important implication for clinical practice in geriatric settings.DOI: 10.29245/2578-2959/2019/4.1181 View / Download Pdf
Catherine So-kum Tang1, 2*, Masao Yogo3
1Department of Psychology, National university of Singapore, Singapore
2Center for Family and Population Research, National University of Singapore, Singapore
3Faculty of Psychology, Doshisha University, Kyoto, Japan
According to the transactional model of stress and coping, socially anxious individuals may rely on online social networking sites (SNS) to avoid challenges and demands of “real life” social situation, leading to their addictive use of SNS. This study examined whether the association between social anxiety and SNS addiction would be mediated by depression symptoms. A total of 1015 university students in Japan completed self-administered questionnaires. Results of bivariate correlation analyses showed that social anxiety, depression, and SNS addiction were significantly related to each other. Relative to men, women reported higher levels of depression and addictive use of SNS. Results of a moderated mediation analysis showed that depression was a significant mediator between social anxiety and SNS addiction, and this mediation effect was moderated by gender. For women, social anxiety exerted an indirect effect on SNS addiction through depression. For men, social anxiety exerted both a direct effect as well as an indirect effect via depression on SNS addiction. Findings suggest that intervention programs that aim to reduce SNS addiction among young adults should include mood management as a core component, and this is particularly relevant for women. Prevention strategies for SNS addiction should also include early detection and identification of depression and social anxiety.DOI: 10.29245/2578-2959/2019/4.1188 View / Download Pdf