Vol 2-3 Commentary

Commentary: Integration of gene expression and GWAS results supports involvement of calcium signaling in Schizophrenia

L. Hertzberg1,2*, E. Domany1

1Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel

2The Emotion-Cognition Research Center, Shalvata Mental Health Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

The number of Genome Wide Association Studies (GWAS) of schizophrenia, as well as that of subjects studied have increased dramatically over the last years. Nevertheless, biologically meaningful interpretation of GWAS results remains very difficult due to the complexity and heterogeneity of both clinical and genetic aspects of schizophrenia, and the small contribution of each single gene to the disease. Our study presented a methodology that integrated GWAS results with gene expression data, and applied it to schizophrenia. Integration of two types of information, of both DNA-level and of messenger RNA (mRNA) level, increases the validity and reliability of the results and improves our understanding of the biological meaning of the GWAS results. We comment here on the methodology used and the main result of our study.

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Vol 2-3 Mini Review

Mini Review:The Mental and Physical Consequences of Chinese Shidu Parents

Qianlan Yin#, Zhuoer Sun#, Weizhi Liu*

Faculty of Psychology and Mental Health, Second Military Medical University, Shanghai, China

“Shidu Parents” (SDP) means parents whose only child has passed away or is disabled to perform the basic social function and daily living activities due to an accident or other events. These parents cannot conceive or adopt another child. Bereavement is a great grief and threat to mental and physical states evidenced by many studies, but SDP are a new and increasing subgroup emerging in this field, especially in China. The goal of this paper is to review the research literature regarding mental and physical health consequences of SDP and the intertwined influence, thus to add to the corresponding assistance from the government.

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